Alipogene tiparvovec
Glybera (alipogene tiparvovec) is a gene pharmaceutical. Alipogene tiparvovec was first approved as Glybera on 2012-10-25. It has been approved in Europe to treat hyperlipoproteinemia type i.
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Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hyperlipoproteinemia type i | D008072 | Orphanet_411 | E78.3 | — | 3 | 2 | — | 2 | 5 |
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Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hyperlipidemias | D006949 | HP_0003077 | E78.5 | — | — | — | — | 2 | 2 |
| Hyperlipoproteinemias | D006951 | HP_0010980 | — | — | — | — | — | 2 | 2 |
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Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Alipogene tiparvovec |
| INN | alipogene tiparvovec |
| Description | Alipogene tiparvovec, sold under the brand name Glybera, is a gene therapy treatment designed to reverse lipoprotein lipase deficiency (LPLD), a rare recessive disorder, due to mutations in LPL, which can cause severe pancreatitis. It was recommended for approval by the European Medicines Agency in July 2012, and approved by the European Commission in November of the same year. It was the first marketing authorisation for a gene therapy treatment in either the European Union or the United States.
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| Classification | Gene |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 929881-05-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2108304 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB13521 |
| UNII ID | 20OK4AFR4Y (ChemIDplus, GSRS) |
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